Red snapper making bones rar file1/30/2023 These findings suggest that RARγ plays an essential role in maintaining stem/progenitor cells during embryonic development and tissue regeneration when the receptor is in its nonligated state. This regenerative response was restored by agonist washout or cotreatment with the RARγ antagonist. Regeneration of the caudal fin was also blocked by RARγ agonist treatment, which was associated with a loss of canonical Wnt signaling. However, there was no loss of Tbx-5-immunopositive lateral plate mesodermal stem/progenitor cells and the block was reversed by agonist washout or by cotreatment with an RARγ antagonist. Pectoral fin outgrowth was blocked by RARγ agonist treatment. There was a loss of Sox 9-immunopositive neural crest stem/progenitor cells in the same anterior regions. Treatment with the RARγ agonist also disrupted formation of tissues arising from cranial neural crest, including cranial bones and anterior neural ganglia. Treatment of zebrafish embryos with an RARγ-specific agonist reduced somite formation and axial length, which was associated with a loss of hoxb13a expression and less-clear alterations in hoxc11a or myoD expression. We have used wild-type and transgenic zebrafish to examine the role of RARγ. However, the function of the different RA receptors (RARs)-RARα, RARβ, and RARγ-is as yet unclear. Retinoic acid (RA) signaling is important to normal development.
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